Endocrine Abstracts

Background: Obesity poses a considerable threat to health, increasing the likelihood of accompanying conditions such as type 2 diabetes, hypertension, dyslipidemia, and cancer. Ageing results in the accumulation of damaging factors leading to the development of chronic diseases. Inflammation levels, telomere length, level of neurocognitive function, metabolic age serve as acknowledged indicators of biological aging. The prevalence of premature ageing in obesity has been eviden...

Carcinoid heart disease (CHD) affects about 20-50% of patients with carcinoid syndrome (CS) and is the main cause of mortality in this group of patients. The 3-year survival rate in patients with CHD is 31% compared to 68% in those without cardiac involvement. The cause of the development of CHD is the flow of serotonin-rich blood, and the lesions affect the right heart (localizing mainly in the endocardium and inner membrane of large vessels). The study aim was to present a s...

Introduction: According to the literature, the CRH test has the highest specificity in excluding ECS (ACTH 93.9%, cortisol 89.4%). A combination of the high dose dexamethasone test (HDDST) and CRH/desmopressin test (CRH/desmopressinT) is used to increase the discriminatory capacity in ACTH-dependent CS.Objectives: This study aims to investigate the response to dynamic tests in ECS patients.Methods: 35 consecutive ECS patients were ...

Introduction: Somatostatin analogues (SSA) are recommended as the first-line systemic therapy, to control tumour growth for advanced or metastatic well-differentiated neuroendocrine tumours (WD NET), with good expression of the somatostatin receptors. [68Ga]Ga-DOTA-SSA PT/CT has become the gold standard in the diagnosis, staging and monitoring therapy, of WD NET.Aim: The aim of the study was to evaluate the predictive role of standardized uptake values (...

Introduction: The data on giant prolactinomas (the rare (3%) subtype of lactotroph PitNET (≥40 mm) ), often causing clinical and therapeutic difficulties are scarce.Aim: We studied clinical/biochemical and treatment outcomes differences between giant and macroprolactinomas.Materials and methods: Consecutive patients with giant prolactinomas ≥40 mm (GP) and macroprolactinomas >10 mm<40 mm (MP) treated in the tert...

Introduction: Pheochromocytoma is a rare, usually benign tumor composed of neuroendocrine (chromaffin) cells of the adrenal medulla. It is the cause of secondary arterial hypertension. The biochemical diagnosis of a pheochromocytoma is based on the determination of concentration/excretion of catecholamine metabolites in blood or urine. The most sensitive biomarkers in the biochemical diagnosis of pheochromocytoma are plasma free methanephrines (metanephrine, normetanephrine an...

Background: PRRT is an effective treatment option (especially for controlling disease progression)for disseminated neuroendocrine tumors (NETs), with good expression of the somatostatin receptors. Despite significant progress in NET personalized management, searching for novel predictive and prognostic factors of response to PRRT is crucial for more effective follow-up, better treatment choices leading to more favorable final outcome. Some recent studies indicate that the resp...

Introduction: Diagnostic delay remains significant among the patients with acromegaly, even though the disease awareness has improved over the years.Aim: The aim was to investigate the diagnostic delay and symptoms present at diagnosis of acromegaly among the newly-diagnosed patients.Material and methods: 72 consecutive patients diagnosed with acromegaly between 01.2014 and 12.2021 were evaluated. Division into groups based on: gen...

Silent corticotroph pituitary neuroendocrine tumours (PiTNETs) are a subtype of nonfunctioning PiTNETs, that present positive immunostaining for adrenocorticotropin (ACTH) and/or show the expression of the transcription factor T-PIT without clinical signs of hypercortisolemia. They constitute 20% of all corticotroph PitNETs and manifest in most cases as macroadenoma with suprasellar extension and a higher tendency to apoplexy. We present a 33-year-old male with aggressive cour...

Somatic cells of the seminiferous epithelium, called Sertoli cells, play a key role in germ cell development and maintenance of proper course of spermatogenesis. Although androgens are considered the main regulators of Sertoli cell activity, recent studies indicate that their metabolites, estrogens, also influence Sertoli cell function. Estrogens, act mainly through nuclear estrogen receptors α and β (ERα, ERβ), however non-classical signaling via ...